The Stem Cell Channel
Stem cell science is changing medicine and our understanding of human development. The Stem Cell Channel takes you into the labs where cutting edge-research takes place, introduces you to the scientists leading the way, and breaks down how these amazing discoveries impact everyday life and health.
When Science Meets Fiction - Alysson Muotri, Tim Disney and the Movie "William"
6/15/2019
The science of stem cells allows us to understand our genome by comparing our own genome to that of our ancient cousins – the Neanderthal.

The motion picture William is a story about a Neanderthal living among modern humans. The director of the UC San Diego Stem Cell Program Alysson Muotri was able to visit with the creator and director, Tim Disney, to discuss the real issues explored by this fantasy.
Neanderthal Among Us? Science Meets Fiction - A Discussion of Tim Disney's Motion Picture "William"
6/8/2019
What makes us human is a question that not only science asks, but all disciplines of mind from philosophy to religion to sociology and ethics, and even to storytelling and the arts. Tim Disney's new movie "William" is about a Neanderthal living in the modern world forces us to ask that same and many other questions. Director of the UC San Diego Stem Cell Program Alysson Muotri brought together a panel of experts from across a spectrum of disciplines to discuss those...
Curing Leukemia: From Zebrafish to Alpha Clinics
5/31/2019
Alysson Muotri explores how discoveries made using tiny Zebrafish will lead to cures for blood diseases like leukemia using stem cells, and how those cures will reach patients through California's network of Alpha Clinics.
From Zebrafish to Leukemia
5/25/2019
David Traver explores how discoveries made using tiny Zebrafish will lead to cures for blood diseases like leukemia using stem cells.
Is Most of Your DNA Junk?
5/24/2019
Alysson Muotri and top geneticists Rusty Gage and Miles Wilkinson explore the fact that ninety-nine percent of human DNA doesn't code for anything used by the human body.
California's Alpha Clinics: Bringing Science to the Clinic, Creating Cures for You
5/22/2019
Alysson Muotri and Catriona Jamieson discuss how cutting-edge stem-cell-based cures will reach patients through California's network of Alpha Clinics.
The Piwi-piRNA Pathway: A New Paradigm of Gene Regulation with Haifan Lin
5/17/2019
Professor at Yale University and the founding director of the Yale Stem Cell Center Haifan Lin talks about how the discoveries of small non-coding RNAs, including PIWI-interacting RNAs (piRNAs), have significantly expanded the RNA world.
Re-constructing Brains in the Lab to Revolutionize Neuroscience - Exploring Ethics
3/23/2019
Cerebral organoids, also known as mini-brains, are tridimensional self-organized structures derived from stem cells that resemble the early stages of the human embryonic brain. This new tool allows researchers to explore fundamental neurodevelopmental steps otherwise inaccessible in utero experimentally. Alysson Muotri, UC San Diego Stem Cell Program, explains how mini brains are generated in his lab and how this strategy can create novel therapeutical insights on neurogenetic...
Development of Therapeutic Approaches for Muscle Disease Using Human Pluripotent Stem Cells
3/7/2019
April Pyle, Department of Microbiology, Immunology and Molecular Genetics at UCLA, uses multi-disciplinary approaches to study human pluripotent stem cell biology and differentiation of these cells for use in regenerative medicine. She studies both basic aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy.
Ethical Boundaries of Research with Human Embryos - Exploring Ethics
10/31/2018
Since stem cells were first cultured from human embryos in 1998, the ethical considerations surrounding this technology have been widely debated, leading to establishment of limits on how this research is conducted and funded. Learn more about these scientific advances, the implications of these discoveries for human health, and consider how ethical norms can best be integrated into research and practice. Recorded on 10/03/2018.
Getting to the Heart of Cell Fate Control
9/28/2018
Laurie A. Boyer, PhD, Associate Professor of Biology and Biological Engineering at MIT, discusses her work studying cell fate and cardiac regeneration. She shares how her lab is dissecting the gene regulatory mechanisms that control lineage commitment during heart development and congenital heart defects and applying this knowledge toward engineering cardiac tissues.
TBR1 and AUTS2: Sequential Regulators of Gene Expression in Cortical Development with Overlapping Neurodevelopmental Syndromes
8/3/2018
TBR1 and AUTS2, the development of the cerebral cortex, and developmental transcription factors.
CARTA: Imagination and Human Origins: Alysson Muotri - Reconstructing the Neanderthal Mind in a Dish
7/25/2018
Alysson Muotri of UC San Diego's Stem Cell Program discusses his work creating cortical organoids from modern humans and Neanderthal to compare the brains of humans and human predecessors. Recorded on 06/01/2018.
Progenitor Cell-Based Modeling and Treatment of Glial Disease
7/23/2018
Steven A. Goldman, MD, PhD discusses cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. Recorded on 05/10/2018.
CARTA: Cellular & Molecular Explorations of Anthropogeny - Rick Livesey: Understanding Primate Brain Development Using Stem Cell Systems
3/5/2018
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Recorded on 09/29/2017.
Are We Ready to Edit Our Children’s Genes? - Exploring Ethics
12/7/2017
Just ten years ago, questions about editing genomes of the next human generation were largely hypothetical. The prospect of erasing fatal or debilitating diseases was seen as a goal worth pursuing, even as some worried about the slippery slope of using this technology to create "designer babies." Since then, the science has progressed rapidly. We now have a variety of tools that move these possibilities from theoretical to plausible. Based on his own research, as well...
CARTA: Cellular and Molecular Explorations of Anthropogeny - Rick Livesey, Wieland Huttner, Arnold Kriegstein
11/22/2017
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Recorded on 09/29/2017.
Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons
9/12/2017
Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms.
By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation.
Neurons in a Dish: Creating Cellular Models to Study and Treat Autism - On Our Mind
10/19/2016
Cellular modeling may hold the key to unlocking some the most important questions about autism. Alysson R. Muotri, PhD joins William Mobley, MD, PhD to explain how his work is shedding light on not only the pathology of autism but potential new drugs.
Crowdsourcing Science, Parkinson's, and Stem Cells - Exploring Ethics
7/7/2016
Parkinson's disease (PD) affects more than a million people in the US. Jeanne Loring, professor and the founding director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, discusses current research and potential future therapies for PD. In 2012, a partnership of scientists, clinicians, PD patients, and patient advocates was formed to develop a therapy for PD using patients' own skin cells that can be transformed into dopamine neurons, which...
 

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