Stem Cell: Advanced Concepts
Experts bring you in-depth explorations of stem cell research.
Gene Edited Cells: Next Generation of Cancer Therapeutics
Khalid Shah, MS, PhD discusses translating biological therapies into clinical care.
Is Most of Your DNA Junk?
Alysson Muotri and top geneticists Rusty Gage and Miles Wilkinson explore the fact that ninety-nine percent of human DNA doesn't code for anything used by the human body.
California's Alpha Clinics: Bringing Science to the Clinic, Creating Cures for You
Alysson Muotri and Catriona Jamieson discuss how cutting-edge stem-cell-based cures will reach patients through California's network of Alpha Clinics.
The Piwi-piRNA Pathway: A New Paradigm of Gene Regulation with Haifan Lin
Professor at Yale University and the founding director of the Yale Stem Cell Center Haifan Lin talks about how the discoveries of small non-coding RNAs, including PIWI-interacting RNAs (piRNAs), have significantly expanded the RNA world.
Development of Therapeutic Approaches for Muscle Disease Using Human Pluripotent Stem Cells
April Pyle, Department of Microbiology, Immunology and Molecular Genetics at UCLA, uses multi-disciplinary approaches to study human pluripotent stem cell biology and differentiation of these cells for use in regenerative medicine. She studies both basic aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy.
Getting to the Heart of Cell Fate Control
Laurie A. Boyer, PhD, Associate Professor of Biology and Biological Engineering at MIT, discusses her work studying cell fate and cardiac regeneration. She shares how her lab is dissecting the gene regulatory mechanisms that control lineage commitment during heart development and congenital heart defects and applying this knowledge toward engineering cardiac tissues.
TBR1 and AUTS2: Sequential Regulators of Gene Expression in Cortical Development with Overlapping Neurodevelopmental Syndromes
TBR1 and AUTS2, the development of the cerebral cortex, and developmental transcription factors.
Progenitor Cell-Based Modeling and Treatment of Glial Disease
Steven A. Goldman, MD, PhD discusses cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. Recorded on 05/10/2018.
Reconstruindo o cérebro em uma placa de Petri: ocorrência de neuroinflamação causada por retrotransposons- Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons (Portuguese Translation)
Pesquisadores do programa de células-tronco da Universidade da Califórnia em San Diego usaram uma doença rara, a Síndrome de Aicardi Goutieres (AGS), para investigar os mecanismos fundamentais do cérebro. Usando organóides corticais, ou cérebros, em um disco, eles monitoraram o neurodesenvolvimento enquanto descobriram novas informações sobre a correlação entre retrotransposão e...
Reconstrucción cerebral en laboratorio: surgimiento de la neuroinflamación de retrotransposones - Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons (Spanish Translation)
Investigadores en el Programa de Células Madre en UC San Diego han utilizado un raro desorden, Aicardi Goutieres (AGS), para explorar mecanismos fundamentales del cerebro. Utilizando organoides corticales, o cerebros en una placa, han seguido el neurodesarrollo a medida que encontraban nueva información sobre la relación entre los retrotransposones y la neuroinflamación.

Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons
Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms.
By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation.

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