Stalking an Alzheimer Gene Mutation in the Far Mountains of Colombia
Premiere Date: 10/14/2016; 28 minutes


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For the past three decades the largest family in the world with a genetic form of Alzheimer's disease has been tracked. This extended family of some 5,000 individuals live in Antioquia, Colombia among a people who call themselves Paisa. Passing relentlessly through the generations with 100% penetrance is a mutation that causes early onset Alzheimer's disease in its carriers. Dr. Kenneth Kosik explains that the mutation in the Americas likely originated from a Spanish conquistador whose progeny are the members of the family we see today. Recently, interest in the family has grown because they are now participating in a clinical trial intended to delay the onset of the disease. Recorded on 06/30/2016. (#31481)


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