Can wisdom be a safeguard for physical and mental heath during difficult times? What kind of resilience has wisdom provided during the COVID-19 pandemic? Dilip V. Jeste, MD, a geriatric neuropsychiatrist who specializes in successful aging, explains the biological and cognitive roots of wisdom as well as how it can be enhanced and harnessed to combat the negative impacts of loneliness. Recorded on 10/22/2021. (#37591)