Advances in genome sequencing hold tremendous promise for providing answers, tailored therapies and in some case cures for undiagnosed patients. However, how to interpret and act upon volumes of complex genomic data remains a challenge for sequencing providers, physicians and their patients and families. Dr. Jennifer Friedman, Rady Children's Hospital, uses case-based examples to demonstrate promises and pitfalls encountered in application of genomic sequencing to diagnose patients with rare disease. (#30483)