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The blood-brain-barrier (BBB) is a special structure in the body that helps to protect the brain from unwanted toxins and germs. Unfortunately, this barrier can also make it extremely difficult for therapeutics to reach their intended target within brain. Lawrence Livermore Lab scientists describe how combining experimental techniques with computational methods, making use of some of the fastest supercomputers in the world, can speed up the process of optimizing therapeutics to cross the BBB. Recorded on 02/23/2019. (#34467)