On Our Mind
William C. Mobley, Distinguished Professor and Chair of the Department of Neurosciences at UCSD, welcomes experts with wide ranging expertise to discuss the brain. Explore how the brain works, the technologies we can use to harness brain power, and how we can treat disease, and much more.
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Young Latino Scientists Working on Alzheimer's
1/31/2019
More than 5 million Americans are currently diagnosed with Alzheimer's disease, and that number is expected to triple by 2050, without prevention or cure. By 2060, the number of Latinos in the United States living with Alzheimer's disease is projected to increase 832 percent from 379,000 in 2012, to more than 3.5 million. Find out what UC San Diego is doing to both serve this community and catalyze the research careers of investigators from underrepresented groups.
What Role Do Genetics Play in Alzheimer’s? - On Our Mind
10/5/2018
There are different types of genetic influences on people's risk of developing Alzheimer's disease. Douglas Galasko, MD, of the UCSD Shiley-Marcos Alzheimer's Disease Research Center joins William Mobley, MD, PhD to discuss these genes, how they are being studied, and what being a carrier of Alzheimer's associated genes means. Learn more about penetrance and expressivity, genome-wide association studies, and more.
Impact of the Human Genome
11/17/2017
The human genome impacts human health and our risk for psychiatric and developmental disorders. Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics, Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to give a brief overview of the human genome, the blueprint to human development.
Autism and Genetics
10/27/2017
Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics, Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to discuss genetics as they relate to autism and how technology can help pinpoint the genes contributing to the disorder.
Studying the Brain in Real Time with Ralph Greenspan - On Our Mind
8/31/2017
"Basic mechanisms in the brain have universal applications and are the road to medical discovery," says Ralph Greenspan, PhD. Learn more as he joins William Mobley MD, PhD to discuss how his work creating dynamic maps of brain activity is shedding light not only on brain function but how we diagnosis and treat neurological diseases. Dr. Greenspan discusses his work with the national BRAIN Initiative, Cal-BRAIN, and discoveries in his lab at UC San Diego.
Designer DNA Drugs with Don Cleveland - On Our Mind
7/14/2017
Can we turn off the genes responsible for neurodegenerative diseases? Designer DNA drugs are making this possible. By identifying and targeting the genes that drive disease, scientists are moving closer to treatments for ALS, Huntington's disease, and more. Don W. Cleveland, PhD, Department of Cellular and Molecular Medicine, UC San Diego joins William Mobley, MD, PhD to talk about how these drugs work and how they will impact patient care.
Neuroplasticity: Our Adaptable Brain with Nick Spitzer - On Our Mind
6/30/2017
Our neurons talk to each other but the language they use can change depending on what is happening in the environment around them. If the brain can adapt to our world in this way, what are the bigger implications? Nick Spitzer, Division of Biological Sciences, UC San Diego, explains neurotransmitter switching and how that process impacts our physical abilities, disease processes, and more.
The Fast-Track to Hearing Loss: Noise Exposure
6/23/2017
Jeffrey P. Harris, MD, PhD, FACS warns against a significant contributor to hearing loss, exposure to noise. With a little bit of effort we can avoid the devastating effects resulting from noise exposure.
Key Features of Autism
6/2/2017
What is autism? Karen Pierce, PhD, co-director of the UC San Diego Autism Center of Excellence joins William Mobley, MD, PhD to discuss the neurodevelopmental disorder, autism. Watch the entire show to learn about the importance of early detection, creating standardized screenings, the search for diagnostic and prognostic biomarkers, and what parents and pediatricians can do to help children with autism.
Regenerating Hair Cells to Treat Hearing Loss
6/2/2017
Jeffrey P. Harris, MD, PhD, FACS discusses regenerating hair cells in cases of hearing loss. Dr. Harris has pioneered new methods of drug delivery to the inner ear. As a surgeon, he did the first cochlear implant surgery in San Diego county and continues to work with the technology as it advances.
Inner Ear Treatments, Cochlear Implants, Hearing Loss and More: Advances in Otolaryngology with Jeffrey P. Harris - On Our Mind
4/28/2017
Jeffrey P. Harris, MD, PhD, FACS joins William Mobley, MD, PhD for a wide-ranging discussion about the field of otolaryngology. With his background in immunology, Dr. Harris has pioneered new methods of drug delivery to the inner ear. As a surgeon, he did the first cochlear implant surgery in San Diego county and continues to work with the technology as it advances. He discusses current treatments for inner ear problems and looks to the future - including treatments for HPV-related facial...
The Intersection of Behavior and Mental Health Through the Lens of Inflammation, HIV, Alzheimer's Disease and More with Igor Grant - On Our Mind
4/21/2017
Igor Grant, MD, FRCP(C) pursues research that addresses real world behavioral problems. Studying the intersection of drugs of abuse (primarily methamphetamine) and infection, his work sheds light on the basic mechanisms of injury for people with HIV. He examines inflammation in the context of neurological disorders and measures the impact of chronic stress on Alzheimer's disease caregivers. Dr. Grant joins William Mobley, MD, PhD to discuss his life in science and his fascinating work.
New Genetic Tools to Treat Autism and Pediatric Neurological Disorders with Joseph Gleeson - On Our Mind
12/30/2016
Joseph G. Gleeson, MD, Rady Professor of Neuroscience at UC San Diego joins William Mobley, MD, PhD to his work sequencing DNA to find treatments for neurodevelopmental disorders. Learn more about using a genetic framework to tease out the individual contributors to autism, why implementing rapid DNA sequencing for newborns can make huge impacts, and more.
Diagnosing and Treating Autism with Doris Trauner - On Our Mind
12/30/2016
What are the early signs of autism and how is it diagnosed? Doris A. Trauner MD, distinguished professor in the departments of Neurosciences and Pediatrics at the UC San Diego School of Medicine joins William Mobley, MD, PhD to talk about early indicators, the process of obtaining a diagnosis, finding treatable causes, and identifying the most effective interventions.
Understanding the Genome and the Future of Autism Therapies with Jonathan Sebat - On Our Mind
12/30/2016
How does the genome impact human health and our risk for psychiatric and developmental disorders? What is the interplay between our genes and our environment? Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics, Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to discuss the genetic causes for autism and how technology can help pinpoint those causes and influence potential therapies.
Research Ethics and Advancing the Future of Alzheimer's Disease Research with Ara Khachaturian - On Our Mind
12/16/2016
Ara Khachaturian, PhD, chair and president of the National Biomedical Research Ethics Council joins WIilliam Mobley, MD, PhD to discuss the evolution of biomedical research in Alzheimer's disease and the ethical standards needed to maintain excellent patient care. From institutional review boards (IRB) to industry and academic partnerships, learn how we can support and maintain effective research infrastructure.
The Oncoming Epidemic of Alzheimer's Disease with Maria Carrillo - On Our Mind
12/16/2016
As baby boomers age, an unprecedented number of people will be diagnosed with Alzheimer's disease. The economic and social impacts will be wide reaching from cost of treatment to the effect on caregivers. Maria Carrillo, PhD, Chief Science Officer, Alzheimer's Association joins Willliam Mobley. MD, PhD to discuss what can be done and how government, industry and the Alzheimer's Association are working together on larger scale trials and innovative projects. Recorded on 12/8/2016.
The Quest for Treatments for Alzheimer's Disease with Eric Siemers - On Our Mind
12/16/2016
Eric Siemers, MD, Distinguished Medical Fellow at Eli Lilly and Company joins William Mobley, MD, PhD to discuss clinical trails for Alzheimer's disease. He explains the trial design, results, and future implications of the EXPEDITION3 trial for people with with mild dementia due to Alzheimer's disease. Learn more about potential treatments in the clinical trials pipeline that may impact both the symptoms and pathologies of Alzheimer's disease.
Getting to 2025 for Alzheimer's Disease with Phyllis Ferrell - On Our Mind
12/16/2016
Phyllis Ferrell, Vice President and Global Development Leader for Alzheimer's Disease at Eli Lilly and Company joins William Mobley, MD, PhD to talk about the goal set forth in the National Plan to Address Alzheimer's Disease to "prevent and effectively treat Alzheimer's disease by 2025." Ferrell's shares her work to make Alzheimer's dementia preventable by finding ways to slow disease progression and advocating for early diagnosis. Recorded on 12/8/2016.
Early Diagnosis and Treating Autism - On Our Mind
10/14/2016
What is autism and how can we treat it? Karen Pierce, PhD, co-director of the UC San Diego Autism Center of Excellence joins William Mobley, MD, PhD to define autism and share current research. Learn about the importance of early detection, creating standardized screenings, the search for diagnostic and prognostic biomarkers, and what parents and pediatricians can do to help children with autism.
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