Autism Subtypes: Impact on Research and Clinical Care - UCTV - University of California Television
Autism Subtypes: Impact on Research and Clinical Care
Premiere Date: 10/7/2013; 84 minutes


Copy the following code and paste it into your web page to embed this video:

The transition of autism from a diagnostically inclusive, behaviorally-defined disorder to an etiologybased classification system mirrors the history of medical genetics and mental retardation. Beginning in the 1960s, geneticists used physical dysmorphology, biochemical and other laboratory data to delineate the heterogeneity within multiple behaviorally-based phenotypes. To accomplish a similar shift for autism, we identified "phenotypic features" that are present in some individual and relatively discrete, quantifiable and pathophysiologically relevant. Morphologic, physiologic, medical and family history all provide helpful biomarkers that distinguish subsets of autism. Proof that a biomarker splits out an etiologically distinct subset depends on showing differences in outcome measures, clinical course, response to therapy, genetic indicators (sex ratio, recurrence risk) and ultimately identification of separate genes or genetic pathways. (#24421)

add a comment

facebook comments
Sign up for UCTV's monthly e-newsletter:
contact
contact info

feedback

press

watch
where to watch

videos & podcasts

live stream

retransmission

more info
about uctv

faqs

program contributors

university of california

sitemap

follow



©2012 Regents of the University of California. All right reserved. Terms and Conditions of Use.