The Brain Channel
On Our Mind
William C. Mobley, Distinguished Professor and Chair of the Department of Neurosciences at UCSD, welcomes experts with wide ranging expertise to discuss the brain. Explore how the brain works, the technologies we can use to harness brain power, and how we can treat disease, and much more.

Date: 8/7/2017
Our neurons talk to each other but the language they use can change depending on what is happening in the environment around them. If the brain can adapt to our world in this way, what are the bigger implications? Nick Spitzer, Division of Biological Sciences, UC San Diego, explains neurotransmitter switching and how that process impacts our physical abilities, disease processes, and more.

Date: 7/17/2017
Jeffrey P. Harris, MD, PhD, FACS discusses regenerating hair cells in cases of hearing loss. Dr. Harris has pioneered new methods of drug delivery to the inner ear. As a surgeon, he did the first cochlear implant surgery in San Diego county and continues to work with the technology as it advances.

Date: 7/14/2017
Can we turn off the genes responsible for neurodegenerative diseases? Designer DNA drugs are making this possible. By identifying and targeting the genes that drive disease, scientists are moving closer to treatments for ALS, Huntington's disease, and more. Don W. Cleveland, PhD, Department of Cellular and Molecular Medicine, UC San Diego joins William Mobley, MD, PhD to talk about how these drugs work and how they will impact patient care.

Date: 6/30/2017
Jeffrey P. Harris, MD, PhD, FACS warns against a significant contributor to hearing loss, exposure to noise. With a little bit of effort we can avoid the devastating effects resulting from noise exposure.

Date: 6/29/2017
Jeffrey P. Harris, MD, PhD, FACS joins William Mobley, MD, PhD for a wide-ranging discussion about the field of otolaryngology. With his background in immunology, Dr. Harris has pioneered new methods of drug delivery to the inner ear. As a surgeon, he did the first cochlear implant surgery in San Diego county and continues to work with the technology as it advances. He discusses current treatments for inner ear problems and looks to the future - including treatments for HPV-related facial cancers, regenerating hair cells in cases of hearing loss, the brain's response to cochlear implants and more.

Date: 6/5/2017
What is autism? Karen Piece, PhD, co-director of the UC San Diego Autism Center of Excellence joins William Mobley, MD, PhD to discuss the neurodevelopmental disorder, autism. Watch the entire show to learn about the importance of early detection, creating standardized screenings, the search for diagnostic and prognostic biomarkers, and what parents and pediatricians can do to help children with autism.

Date: 5/9/2017
Igor Grant, MD, FRCP(C) pursues research that addresses real world behavioral problems. Studying the intersection of drugs of abuse (primarily methamphetamine) and infection, his work sheds light on the basic mechanisms of injury for people with HIV. He examines inflammation in the context of neurological disorders and measures the impact of chronic stress on Alzheimer's disease caregivers. Dr. Grant joins William Mobley, MD, PhD to discuss his life in science and his fascinating work.

Date: 4/24/2017
How does the genome impact human health and our risk for psychiatric and developmental disorders? What is the interplay between our genes and our environment? Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to discuss the genetic causes for autism and how technology can help pinpoint those causes and influence potential therapies.

Date: 4/10/2017
Eric Siemers, MD, Distinguished Medical Fellow at Eli Lilly and Company joins William Mobley, MD, PhD to discuss clinical trails for Alzheimer's disease. He explains the trial design, results, and future implications of the EXPEDITION3 trial for people with with mild dementia due to Alzheimer's disease. Learn more about potential treatments in the clinical trials pipeline that may impact both the symptoms and pathologies of Alzheimer's disease.

Date: 2/23/2017
As baby boomers age, an unprecedented number of people will be diagnosed with Alzheimer's disease. The economic and social impacts will be wide reaching from cost of treatment to the effect on caregivers. Maria Carrillo, PhD, Chief Science Officer, Alzheimer's Association joins Willliam Mobley. MD, PhD to discuss what can be done and how government, industry and the Alzheimer's Association are working together on larger scale trials and innovative projects. Recorded on 12/8/2016.

Date: 2/13/2017
What are the early signs of autism and how is it diagnosed? Doris A. Trauner MD, distinguished professor in the departments of Neurosciences and Pediatrics at the UC San Diego School of Medicine joins William Mobley, MD, PhD to talk about early indicators, the process of obtaining a diagnosis, finding treatable causes, and identifying the most effective interventions.

Date: 1/19/2017
Ara Khachaturian, PhD, chair and president of the National Biomedical Research Ethics Council joins WIilliam Mobley, MD, PhD to discuss the evolution of biomedical research in Alzheimer's disease and the ethical standards needed to maintain excellent patient care. From institutional review boards (IRB) to industry and academic partnerships, learn how we can support and maintain effective research infrastructure.

Date: 1/16/2017
Phyllis Ferrell, Vice President and Global Development Leader for Alzheimer's Disease at Eli Lilly and Company joins William Mobley, MD, PhD to talk about the goal set forth in the National Plan to Address Alzheimer's Disease to "prevent and effectively treat Alzheimer's disease by 2025." Ferrell's shares her work to make Alzheimer's dementia preventable by finding ways to slow disease progression and advocating for early diagnosis. Recorded on 12/8/2016.

Date: 12/30/2016
Joseph G. Gleeson, MD, Rady Professor of Neuroscience at UC San Diego joins William Mobley, MD, PhD to his work sequencing DNA to find treatments for neurodevelopmental disorders. Learn more about using a genetic framework to tease out the individual contributors to autism, why implementing rapid DNA sequencing for newborns can make huge impacts, and more.

Date: 10/19/2016
Cellular modeling may hold the key to unlocking some the most important questions about autism. Alysson R. Muotri, PhD joins William Mobley, MD, PhD to explain how his work is shedding light on not only the pathology of autism but potential new drugs.

Date: 10/19/2016
What is autism and how can we treat it? Karen Piece, PhD, co-director of the UC San Diego Autism Center of Excellence joins William Mobley, MD, PhD to define autism and share current research. Learn about the importance of early detection, creating standardized screenings, the search for diagnostic and prognostic biomarkers, and what parents and pediatricians can do to help children with autism.

Date: 6/2/2016
While Parkinson's disease is widely known as a motion disorder, it affects other areas of the brain including cognition. Bill Mobley welcomes Vincent Filoteo in a discussion of his efforts to understand these effects both as early signs of the disease and to devise treatments to ameliorate these cognitive effects.

Date: 5/9/2016
Helping patients and their families while conducting research to better understand and treat the disease are the goals of UC San Diego's Huntington's program. Dr. Jody Corey-Bloom explains.

Date: 5/5/2016
Bill Mobley welcomes Albert La Spada as they explore his work using many approaches to uncover the molecular bases of neurodegenerative diseases in a search for treatments.

Date: 5/2/2016
Bill Mobley welcomes epidemiologist Harvey Checkoway in a fascinating discussion about exploring and revealing environmental factors contributing to Parkinson's Disease and other motion disorders.

Date: 5/2/2016
Inspired by the legacy of his father, boxing legend Archie Moore, Billy Moore has dedicated his life to helping kids find their footing in the world through boxing. His Any Body Can Youth Foundation opens its doors daily to local youth for training, tutoring, and fellowship. Billy Moore sits down with William Mobley, MD, PhD to talk about his father, the foundation, and his vision for helping kids.

Date: 5/2/2016
Bill Mobley welcomes Fatta Nahab whose novel use of brain imaging techniques is revealing clues in understanding and developing new therapies to treat movement disorders. Recorded on 02/29/2016.

Date: 4/20/2016
Bill Mobley welcomes Eliezer Masliah who explains how he has worked on advancing our understanding of the pathogenesis and similarities in Neurodegenerative disorders through observations of pathology and genetics.

Date: 1/7/2016
Approximately 1 million Americans currently live with Parkinson's disease. Irene Litvan, MD joins our host William Mobley, MD, PhD to discuss the latest advances in PD research. Learn about the progression of the disease, early warning signs, and promising new therapies currently in development.

Date: 1/7/2016
Progressive supranuclear palsy (PSP) is a condition that affects the brain with symptoms that worsen over time. Irene Litvan, MD joins William Mobley, MD, PhD to talk about the signs and symptoms of PSP, disease progression, genetic issues, as well as potential treatments on the horizon.

Date: 7/14/2015
Six in ten people with dementia will wander. Hear about the programs that are available to help bring them home safe. Linda Cho, executive director of Stellar care, joins William Mobley, MD, PhD to discuss the problem of wandering and how to create a home environment that facilitates safety and comfort.

Date: 6/25/2015
V.S. Ramachandran, PhD is looking to solve life's big questions by taking a different path. In studying the oddities and anomalies of the brain he hopes to illuminate the mysteries of normal brain function. A pioneer in the study of phantom limbs, Ramanchandran joins William Mobley, MD, PhD to discuss his fascinating career and his scientific process. Hear the latest on xenomelia, sleep paralysis, synesthesia and more.

Date: 5/7/2015
Jean-Pierre Changeux reflects on his scientific journey and shares insights into his research with Dr. William Mobley. This wide-ranging discussion takes a deeper look into Changeux's early work with bacteria to more recent findings on the chemistry of consciousness.

Date: 3/25/2015
How can communities better support the growing number of people affected by Alzheimer's disease? Mary Ball, president and CEO of the Alzheimer's Association, San Diego and Imperial Counties Chapter joins William Mobley, MD, PhD to discuss how her organization is trying to make a difference through information, support, and partnerships with local government.

Date: 3/16/2015
Choosing residential care for a loved one if often a difficult decision. Linda Cho, executive director of Stellar care, joins William Mobley, MD, PhD to talk about the new models of residential care, family involvement, care with dignity and more.

Date: 2/16/2015
What insights into Alzheimer's disease can cutting edge imaging techniques reveal? James Brewer, MD, PhD joins William Mobley, MD, PhD to discuss how this unique wiindow into the brain can be used to study the progression of the disease as well as help test new therapies.

Date: 2/5/2015
How can we create more effective drugs for Alzheimer's disease? Michael Jackson, PhD joins William Mobley, MD, PhD to discuss the process of turning an idea into a drug. Creating connectivity between basic scientists, pharmaceutical companies, and the physicians on the front lines is a critical step as is embracing new ideas that may lead us to new therapeutic options.

Date: 2/2/2015
The biomarkers for many diseases can be found through blood tests, can Alzheimer's disease eventually be diagnosed this way? Douglas R. Galasko, MD joins William Mobley, MD, PhD to discuss the search for these biomarkers and how they might one day lead to earlier and more accurate diagnoses of the disease, improved therapies, clear maps of progression, and much more.

Date: 12/1/2014
Caring for a loved one with dementia can be overwhelming. Dealing with the day to day realities while managing your own mental and physical well being is a constant challenge. Darlene Shiley cared for her late husband as he dealt with dementia. She shares her story with Dr. William Mobley and stresses the importance of palliative care.

Date: 11/6/2014
Can stem cells be a weapon in the fight against Alzheimer's disease? Larry Goldstein, PhD director the the UC San Diego Stem Cell Program, joins William Mobley, MD, PhD to discuss how stem cells work and what possibilities they may unlock.

Date: 10/22/2014
There are more than 5 million Americans living with Alzheimer's disease. The impacts are felt not only by the patients but by their family, their caregivers, and the community at large. San Diego County Supervisor Dianne Jacob joins William Mobley, MD, PhD to discuss how we can better manage this disease from a public policy standpoint.

Date: 10/16/2014
How do you know when memory problems become more than just problems? Diagnosing Alzheimer's disease can be challenging but new tests and scientific insight are making the process simpler and more accurate. Michael Rafii, MD, PhD joins William Mobley, MD, PhD to discuss when to see a doctor, what to expect during the diagnosis process, and other valuable information for patients and their families.

Date: 10/2/2014
How do we create and store memories? Larry Squire PhD joins William Mobley MD, PhD to dissect these processes and how we might use this knowledge to aid in the fight against Alzheimer's disease.

Date: 10/1/2014
By the age of 40, nearly all people with Down syndrome have the plaques and tangles associated with Alzheimer's disease. Michael Rafii, MD, PhD joins William Mobley, MD, PhD to discuss why this occurs, the prevalence and progression of Alzheimer's disease, potential treatment models and current research affecting this predisposed population.

Date: 9/15/2014
Early detection of Alzheimer's disease - before symptoms are visible - may be a key to stopping the disease's progression. What warning signs are researchers looking for and what tools can they use? Paul Aisen, MD joins William Mobley, MD, PhD to discuss optimal assessments for diagnosing the disease, novel tools making earlier diagnosis possible, and the road map to developing drugs to slow, halt, and prevent Alzheimer's. Recorded on 7/29/2014.

Date: 9/15/2014
Can lost memories be found? Is it possible to erase a memory from the brain? Roberto Malinow, MD, PhD joins William Mobley MD,PhD to discuss his recent study where memories were not only erased but restored in rats. Learn about how synapses in the brain function and how findings of this study could lead to breakthroughs in the treatment of Alzheimer's disease.

Date: 9/8/2014
What does the future hold for the treatment of Alzheimer's disease? Steven L. Wagner, PhD joins William Mobley, MD, PhD to discuss the development of new drugs to aid in the fight. Wagner describes amyloid plaques as "the cholesterol of the brain" and is working to find a way to suppress its adverse effects.

Date: 8/13/2014
Steve Hickman, Psy.D., Executive Director of the UC San Diego Center for Mindfulness joins William Mobley, MD, PhD for a discussion of how to be present in the moment and leverage the practice of mindfulness to stay engaged, focused, and fulfilled.

Date: 6/23/2014
Can the secrets of the brain be decoded? Learn how finding meaningful patterns using big data is leading the way to big discoveries. Arthur W. Toga, PhD, joins William Mobley, MD, PhD to discuss scientific approaches to mapping the brain and its functions.

Date: 3/17/2014
Is there a science of the soul? Does how we think about the brain define how we think about ourselves? Patricia Churchland, B. Phil., LLD (hon), Professor Emeritus, Department of Philosophy at UC San Diego, joins William Mobley, MD, PhD for a deeper look at the connections between neuroscience and philosophy.

Date: 10/4/2013
William Mobley, MD, PhD,, Distinguished Professor and Chair of the UC San Diego Department of Neurosciences, introduces you to the Brain Channel's new series about the fascinating facets of our brains.